个人简介

方雅静，博士、副教授、哥本哈根大学博士后，博士/硕士生导师，bw西汉姆联热带健康食品生物制造团队，海南省“南海新星”教育人才（2025），海南自由贸易港D类高层次人才。主要研究领域为热带传统食品生物制造，具体包括1）：益生菌及后生元产品开发及其抗氧化、抗炎和抗肿瘤等营养与功能评价；2）植物化学物的肠道吸收、代谢的构效关系及作用机制；3）：热带作物（如胡椒、咖啡等）新产品开发、活性成分鉴定及活性机制研究。目前以第一作者/通讯作者发表SCI论文16篇，封面文章1篇，受邀担任Frontiers in Nutrition和Science & Technology NEXUS杂志副主编，主持国家自然科学基金青年基金1项、海南省国际科技合作项目1项，“南海新星”教育人才项目1项，海南省自然科学基金1项、海口市科技计划项目1项和横向课题2项；参与国家自然科学基金地区基金项目、海南省重点研发项目等。

教育背景

2012.09～2018.06，华中农业大学，食品科学专业，工学博士（直博）

2008.09～2012.06，华中农业大学，食品质量与安全专业，理学学士学位

工作经历

2021.06～至今 bw西汉姆联官网平台，bw西汉姆联，副教授

2019.01～2021.03哥本哈根大学，食品科学公司，博士后

科研项目

1. 海南省南海新星项目教育人才，AI赋能与科研引领双轮 驱动下自贸港食品微生物安全创新人才培养模式探索，2026-2028，10万，在研，主持；

2. 海南省国际科技合作研发项目，超临界CO2萃取海南胡椒精油的风味成分及其抗炎活性构效关系研究，2026-2028，100万，在研，主持；

3. 海南省重点研发项目，基于豆粕型肠炎防控的海南鲷饲料键制备技术与应用，2026-2028，298万，在研，主持；

4. 国家自然科学基金青年基金项目，基于P-糖蛋白抑制作用促进二氢槲皮素肠吸收的分子机制，2024-2026，30万，在研，主持；
5.  bw西汉姆联官网平台其他类高层次人才启动经费，柑橘类黄酮协同抑制肠道外排蛋白与相代谢酶偶联作用的分子机制，2021-2026，10万，在研，主持；
6.  海南省自然科学基金青年基金，椰子水品质评价体系的构建，2022至2025，6万，结题，主持；
7.  深圳保时健生物工程有限公司技术开发合同，功能性益生菌筛选和开发，2024-2025，25万，结题，主持；
8.  海南省壹升实业有限公司技术开发合同，益智红茶产品开发与品质评价，2021-2024，10万，结题，主持；
9.  海口市科技计划项目，生椰拿铁产品制备关键研究与产品开发，2022-2025，60万，结题，参与；
10.  丹麦乳品研究基金会资助项目“UHT treatment and storage effects on the biological quality of liquid infant formulas超高温瞬时灭菌处理与贮藏对液态婴儿配方奶的生物活性影响”，2020-2023，200万，结题，参与；
11.  丹麦食品、农业与水产部、欧洲最大乳品企业爱氏晨曦Arla与哥本哈根大学食品系合作项目“Tailored processing of bioactive ingredients for high-end infant formula高端婴儿配方奶的活性配料的定制加工工艺”，2019-2024，1140万，结题，参与。

文章著作

1. Song H, Cao W, Chen X, Peng S, Sun W, Yang X, Salah M, Farag M A, Fang Y*. Improvement of the intestinal absorption of dihydroquercetin (DHQ) by flavonoids via inhibiting P-glycoprotein (P-gp)-mediated efflux in P-gp overexpressed KB/MDR1 cells and Caco-2 monolayers. Journal of Agricultural and Food Chemistry. 2026, 74:4823-4836.

2. Sun W, Song H, Chen X, Yang X, Zeng C, Farag MA, Fang Y*, Zhang W*. The effect of adding different tea powders on bioactive compounds, antioxidant and anti-inflammatory activities of coconut latte in THP-1 macrophages via NF-κB pathway. Science and Technology Nexus.

3. Song H#, Fang Y#, Chen X, Sun W, Yang X, Salah M, Farag M A, Zhang J. Amelioration of lipopolysaccharide (LPS)-induced inflammation via MAPK/NF-κB pathway in THP-1 macrophages and polystyrene microplastics (MPS)-induced inflammation, intestinal injury and dysbacteriosis in mice by a tropical coconut water-based postbiotic. Food Science and Human Wellness. 2025.

4. Zhang Z#, Fang Y#, He Y#, Farag M A, Zeng M, Sun Y, Peng S, Jiang S, Zhang X, Chen K, Xu M, Han Z, Zhang J. Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites. NPJ Biofilms Microbiomes. 2024, 10(1):144.

5. Ye Y#, Fang Y#, Engholm-Keller K, Bechshøft M R, Chatterton D E W, Sangild P T, Nguyen D N, Bering S B, Lund M N. Protein digestibility and anti-inflammatory activity of processed whey protein ingredients for infant formula. Journal of Agricultural and Food Chemistry. 2025, 73(9), 5465-5476.

6. Peng S, Wang J, Farag M A, Salah M, Liu L, Fang Y*, Zhang W*. Impact of refining on phytochemicals and anti-inflammatory activity of papaya (Carica papaya L.) seed oil in LPS-stimulated THP-1 cells. Food Chemistry. 2024. 459, 140299.

7. Song H, Xue H, Zhang Z, Wang J, Li A, Zhang J, Luo P, Zhan M, Zhou X, Chen L, and Fang Y*. Amelioration of Type 2 Diabetes Using Four Strains of Lactobacillus Probiotics: Effects on Gut Microbiota Reconstitution-Mediated Regulation of Glucose Homeostasis, Inflammation, and Oxidative Stress in Mice. Journal of Agricultural and Food Chemistry. 2023, 71(51), 20801-20814. (封面文章)

8. Guo Y, Jia Z, Wan L, Cao J, Fang Y*, Zhang W*. Effects of refining process on Camellia vietnamensis oil: Phytochemical composition, antioxidant capacity, and anti-inflammatory activity in THP-1 macrophages. Food Bioscience. 2023, 52, 102440.

9. Zhang W, Chen Y, Yun Y, Li C, Fang Y*, Zhang W*. Discrimination and characterization of different coconut water (CW) by their phenolic composition and volatile organic compounds (VOCs) using LC-MS/MS, HS-SPME-GC-MS, and HS-GC-IMS. Journal of Food Science. 2023, 1-15.

10. Fang Y, Cao W, Xia M, Pan S, Xu X. Transport and interactions of co-incubated bi-functional flavonoids through inhibiting the function of P-glycoprotein (P-gp) using KB/Multidrug-resistant (MDR) cells and rat everted gut sacs. Journal of Agricultural and Food Chemistry. 2022, 70, 1923-1933.

11. Fang Y, Liang F, Xia M, Cao W, Pan S, Wu T, Xu X. Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells. Food and Chemical Toxicology. 2021, 155, 112381.

12. Fang Y, Cao W, Liang F, Xia M, Pan S, Xu X. Structure affinity relationship and docking studies of flavonoids as substrates of multidrug-resistant associated protein 2 (MRP2) in MDCK/MRP2 cells. Food Chemistry, 2019, 291: 101-109.

13. Fang Y, Xia M, Liang F, Cao W, Pan S, Xu X. Establishment and use of human mouth epidermal carcinoma (KB) cells overexpressing P-glycoprotein to characterize structure requirements for flavonoids transported by the efflux transporter. Journal of Agricultural and Food Chemistry. 2019, 67, 8, 2350-2360.

14. Fang Y, Liang F, Liu K, Qaiser S, Pan S, Xu X. Structure characteristics for intestinal uptake of flavonoids in Caco-2 cells. Food Research International. 2018, 106: 353-360.  

15. Fang Y, Cao W, Xia M, Pan S, Xu X. Study of structure and permeability relationship of flavonoids in Caco-2 cells. Nutrients. 2017, 9(12): 1301.  

16. Fang Y, Lu Y, Zang X, Wu T, Qi X, Pan S, Xu X. 3D-QSAR and docking studies of flavonoids as potent Escherichia coli inhibitors. Scientific Reports. 2016, 6, 23634.

获奖

专利

承担教学

（1）本科生课程：《食品生物化学》，《新生入学教育与导学》；（2）研究生课程：国际课程《Advanced Food Chemistry》，国际课程《Protein Modifications in Food Systems: Chemistry and Analysis》

公司产品

目前在读博士研究生1人、硕士研究生4人，欢迎对热带传统食品制造领域感兴趣的同学报考我的研究生。